A disrupter of actin microfilaments impairs sulfonylurea-inhibitory gating of cardiac KATP channels Peter A Brady, Alexey E Alekseev, Luba A Aleksandrova … [et.al]
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The efficacy with wich sulfonylurea drugs inhibit cardiac ATP-sensitive K+ (KATP) channels is reduced during metabolic compromise and cellular contracture. Disruption of the actin microfilament network, wich occurs under similar conditions, reduces the se
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