TY - BOOK AU - Arango,Diana AU - Backhovens,Hubert AU - Broeckhovens,Christine Van AU - Cano,Carlos AU - Cruts,Marc AU - Jacquier,Martine AU - Matallana,Diana AU - Montañes,Patricia AU - Serrano,Martha L AU - Torres,Orlando AU - Villarreal,Elsa TI - Systematic genetic study of Alzheimer disease in Latin America: Mutation frecuencies of the amyloid ß precuesor protein and presenilin in Colombia PY - 2001/// KW - Enfermedad de Alzheimer KW - Bibliografía del INS4 KW - Enfermedades del sistema nervioso KW - Enfermedades neurodegenerativas KW - Precursor de proteína-beta amiloide KW - Colombia N2 - Nearly all mutations in the presenilin 1 (PSEN1), presenilin 2 (PSEN2), and amyloid ß precursor protein (APP) genes lead to early-onset Alzheimer disease (EOAD, onset age at or before 65 years). In order to assess the genetic contribution of these genes i ER -